With only a bugrich codeplex AJAX Toolkit available, professional ASP.Net Developers were forced to count their options outside the Microsoft playfield. Fast amounts of time were and are invested in encorperating Ajax-frameworks into ASP.net. Just think of Backbase, Dojo, Prototype and Yahoo to name a few.
But there is hope If you are a fan of Scott Guthrie it can't be a suprise, Microsoft future direction for their Ajax strategy will be "JQuery". Atleast that is what I expect given the influence that Scott has and the recent beta release of the mvc-framework heavily depending on JQuery.
My experiences with JQuery are amazin: in the very first place it is very very practical. Its amazing what one can accomplish with a few, intuitive, lines of code.
Secondly, the availability of ready-to-use components build on "JQuery" is rapidly increasing.
So my advise: start experimenting with "JQuery" today, and learn the basics.
See:
http://www.jquery.com/